Endocrine Abstracts

Background: The serum concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Pregnancy is associated with increases in plasma lipid profiles. Identifying the genetic determinants could provide novel insights into mechanisms of dyslipidemia and reveal avenues for developing new therapies. The objective of this study was to investigate the impact of six single nucleotide polymorphisms (SNPs) on serum lipid levels during pregnancy.<p ...

Objectives: The most common cause of maternal hyperthyroidism during pregnancy is Graves’ disease (GD). The aim of this study was to investigate the perinatal complications and the risk of thyroid dysfunction at early childhood of mothers with GD during pregnancy.Method: Pregnant women with GD (n=93) and aged-matched randomly selected healthy pregnant women (n=140) were recruited retrospectively. The prenatal and newborn data were coll...

Background: Type 2 diabetic (T2D) patients have alterations in the gut microbiota composition, compared to healthy individuals. Such alterations may play a role in the pathogenesis of T2D and insulin resistance. Bifidobacteria and Lactobacillus are among the most predominant bacteria found in human gut. They can also easily be added in probiotic preparations, thus making them ideal agents for therapeutic interventions. In this study, we aimed to determine if there were alterat...

Thus far, approximately 30 loci influencing body mass index (BMI) and the risk of obesity have been identified. In this study, we aimed to examine the individual and joint associations of 23 BMI-associated loci identified from recent genome-wide association studies in Caucasians with obesity risk in young Chinese. Birth weight reflects prenatal metabolic adaption and has been related to later-life obesity risk. We particularly assessed whether these genetic variants interacted...